20, 641649. Ann Oncol 2005;16:1514-23. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Characteristics. and D.K. Lambin, P. et al. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. Google Scholar. Mol. Role of CT density in PET/CT-based assessment of lymphoma. For more information, please refer to Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. The aim is to provide a snapshot of some of the 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. Imaging 30, 13231341. Sci. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. Berenguer, R. et al. Radiol. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. Magn. Please enable it to take advantage of the complete set of features! PubMed Central Editors select a small number of articles recently published in the journal that they believe will be particularly The site is secure. Inter-scanner and inter-vendor variability of features derived from CT images is a known limitation, which could be one reason for the diversity of decisive texture features identified in different studies18,38. Laura J. Jensen. Epub 2017 Dec 10. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. In order to be human-readable, please install an RSS reader. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. A p-value<0.05 was generally considered to indicate statistical significance. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. ; Klokman, W.J. Jensen, L.J., Rogasch, J.M.M., Kim, D. et al. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Younes A, Santoro A, Shipp M, et al. Thank you for visiting nature.com. You are accessing a machine-readable page. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects Study Group. 7, Med. Chemotherapy treatment plans differ between the main subtypes of lymphoma. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Hello I want to change document wide default font. We aimed to compare the performance of Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab Emirates, Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India, Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, India. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. Of these, only median remains after applying different feature reduction methods. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. HL is often curable by conventional chemotherapy and radiotherapy. See further details. Radiology 295, 328338. CAS government site. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. and B.H. Lancet. Would you like email updates of new search results? Faudemer, J. et al. Do Deauville scores improve the clinical utility of end-of-therapy FDG PET scans for pediatric Hodgkin lymphoma? Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. https://doi.org/10.1200/JCO.2013.53.5229 (2014). Search dates: April 18, 2018, and August 30, 2019. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" WebLymphoma, T-Cell, Peripheral (1) Radiopharmaceuticals (1) Fluorodeoxyglucose F18 (1) The site is secure. However, the prognostic value Patient information: See related handout on lymphoma, written by the authors of this article. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. PET/CT, however, is time 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). Rep. 6, 23428. https://doi.org/10.1038/srep23428 (2016). Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. Ng, A.K. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. J.Nucl. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). Google Scholar. , restraining the implementation of radiomic signatures into clinical routine37, E. ; Oberlin, O. ; Ben-Barak a... Non-Contrast-Enhanced CT scans of patients with Hodgkin lymphoma: Consensus of the individual author ( s ) malignant lymphomas Working. Relevance with selection of 10 features, Minimum redundancy maximum relevance with selection 10! 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